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GNAI3, Active

Recombinant human GNAI3 (2-end) was expressed in E.coli cells using an N-terminal GST tag.
Catalog No. G123-310G


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Catalog No. Pack Size Price (USD)
G123-310G-05 5 ug $160
G123-310G-10 10 ug $226
G123-310G-BULK BULK Contact Us  


Overview:

Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. G protein subunit alpha i3 (GNAI3) stimulates the activity of receptor-regulated K+ channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.


Gene Aliases:

87U6; ARCND1


Genbank Number:


References:


1. Mattera R, et al: Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels. J Biol Chem. 1989 Jan 5;264(1):465-71.

2. Cho H, et al: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55.

3. http://www.uniprot.org/uniprot/P08754


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

65 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Cancer, Inflammation, Invasion/Metastasis, Metabolic Disorder


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  GNAZ Protein, G131-30G


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