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DMOG

Inhibits Jumonji C Domain Containing Proteins
Catalog No. J48-904


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Catalog No. Pack Size Price (USD)
J48-904-50 50 mg $90
J48-904-100 100 mg $165
J48-904-BULK BULK Contact Us  


Overview:

Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 uM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation4. Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage5.

References:


1. TM Asikainen et al. Proc. Natl. Acad. Sci. USA 2005 102:10212

2. P Jaakkola et al. Science 2001 292:468

3. S. Hamada et al. Bioorg. Med. Chem. Lett. 2009 19:2852

4. DJ Lomb et al. Mol. Pharmacol. 2009 75:1198

5. L Xie et al. J. Clin. Invest. 2012 122:2827


CAS Registry Number:

89464-63-1


Molecular Formula:

C6H9NO5


Appearance:

White to off-white solid


Melting Point:

46-48oC


Molecular Weight:

175.1


Purity:

>98%


Solubilization:

May be dissolved in DMSO (30 mg/ml), ethanol (25 mg/ml), or water (30 mg/ml)


Aliases:

N-(2-Methoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation



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