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RG-108

DNA Methyltransferase Inhibitor
Catalog No. D353-904C


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Catalog No. Pack Size Price (USD)
D353-904C-5 5 mg $80
D353-904C-25 25 mg $315
D353-904C-BULK BULK Contact Us  


Overview:

A non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. Enhances the reversion of neural progenitor cells to the pluripotent state3.

References:


1. B Brueckner et al. Cancer Res. 2005 65:6305

2. C Stresemann et al. Cancer Res. 2006 66:2794

3. I Szablowska-Gadomska et al. Acta Neurobiol Exp. 2012 72:337


CAS Registry Number:

48208-26-0


Molecular Formula:

C19H14N2O4


Appearance:

Tan powder


Melting Point:

104oC


Molecular Weight:

334.3


Purity:

>98% (TLC)


Solubilization:

May be dissolved in DMSO (100 mg/ml); or ethanol (100 mg/ml)


Aliases:

N-Phthalyl-L-tryptophan


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



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