Overview:

VAV3 (Vav guanine nucleotide exchange factor 3) is a member of the Vav family of signaling proteins, known for its guanine nucleotide exchange factor (GEF) activity and its involvement in cell signaling pathways, particularly in cytoskeletal dynamics and cell migration. SH3 domains are approximately 50-70 amino acids in length that are known to mediate protein-protein interactions, often with proline-rich motifs in target proteins. These interactions play a critical role in the formation of signaling complexes and the regulation of various cellular processes.

Genbank Number:

NM_006113.5

References:

1. Bustelo XR. Vav family exchange factors: an integrated regulatory and functional view. Small GTPases. 2014;5:e973757. doi:10.4161/sgtp.28001
2. Movilla N, Bustelo XR. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol. 1999;19(11):7870-7885. doi:10.1128/MCB.19.11.7870
3. Katzav S. Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Cancer Lett. 2007;255(2):241-254. doi:10.1016/j.canlet.2007.03.011