Overview:

Cyclin D1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle that functions as regulators of CDK kinases. Cyclin D1 is the regulatory subunit of a holoenzyme that phosphorylates and inactivates the RB protein and promotes progression through the G1-S phase of the cell cycle in a manner dependent on cyclin-dependent kinases, or CDKs. Cyclin D1 plays pivotal roles in the development of several human cancers, including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (1). Cyclin D1 also coordinates mitochondrial function and nuclear DNA synthesis (2).

Gene Aliases:

BCL1, PRAD1, U21B31, D11S287E

Genbank Number:

NM_053056

References:

1. Fu, M. et.al: Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145: 5439-5447, 2004.

2. Wang, C.et.al: Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc. Nat. Acad. Sci. 103: 11567-11572, 2006.