Recombinant full-length human NEK7 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N09-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
N09-10G-05 | 5 ug | $226 | |
N09-10G-10 | 10 ug | $325 | |
N09-10G-BULK | BULK | Contact Us |
Overview:
NEK7 is a member of the NIMA family of serine/threonine kinases. In contrast to the other documented NIMA-related kinases, NEK7 harbor its catalytic domain in the C-terminus of the protein. Immunofluorescence studies suggest that NEK7 is cytoplasmic and located on chromosome 1 (1). The major protein kinase that is active on the p70 S6 kinase hydrophobic regulatory site (FXXFS/TF/Y) Thr412, was purified from rat liver and identified as NEK7 (2). NEK7 kinase activity is rapidly and efficiently increased by serum deprivation, and may be regulated in a cell cycle-dependent manner.
Genbank Number:
References:
1. Kandli, M. et al: Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96.
2. Belham, C. et al: Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol. 2001 Aug 7;11(15):1155-67.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~63 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
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