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SYK, Active

Recombinant full-length human SYK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S52-10G


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Catalog No. Pack Size Price (USD)
S52-10G-05 5 ug $226
S52-10G-10 10 ug $325
S52-10G-BULK BULK Contact Us  


Overview:

SYK is a non-receptor protein tyrosine kinase that is widely expressed in hematopoietic cells. It is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. In B cells, SYK plays a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement (1). SYK has been shown to act as a potential tumor suppressor in breast cancer. Absence of SYK protein in primary breast tumors is correlated with poor outcomes. SYK deficient cells have increased motility that is restored to normalcy by replacement with wild-type SYK (2).

Genbank Number:


References:


1. Takano, T. et al: Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells. Antioxid Redox Signal. 2002 Jun;4(3):533-41.

2. Navara, C S.: The spleen tyrosine kinase (Syk) in human disease, implications for design of tyrosine kinase inhibitor based therapy. Curr Pharm Des. 2004;10(15):1739-44.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~100kDa



RESEARCH AREAS

AKT/PKB Pathway, Cancer, Cardiovascular Disease, Cellular Stress, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway


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