Recombinant human c-MER (A708S) (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M51-12BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M51-12BG-05 | 5 ug | $226 | |
M51-12BG-10 | 10 ug | $325 | |
M51-12BG-BULK | BULK | Contact Us |
Overview:
c-MER is a member of the TYRO3/AXL/MER (TAM) receptor kinase family which encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses (1). c-MER is essential regulators of mammalian spermatogenesis (2). Mutations in c-MER gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Gene Aliases:
MERTK
Genbank Number:
References:
1. Rothlin, C. V.et.al: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.
2. Lu, Q.et.al: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728, 1999.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~60 kDa
Zhang Zaihui et al., Discovery of novel TAM family kinase inhibitors Cancer Research April 2014 10.1158/1538-7445.AM2014-2716
Zhang Zaihui et al., Novel and selective Axl inhibitors Cancer Research April 2014 10.1158/1538-7445.AM2014-1746
Abu-Thuraiaa Afnan et al., Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion Molecular and Cellular Biology October 2014 10.1128/MCB.00764-14
et al., Regulation of ferredoxin-catalyzed photosynthetic phosphorylations. Proceedings of the National Academy of Sciences of the United States of America December 1975
Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, Neurobiology
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