Recombinant full-length human METTL16 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M336-380G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M336-380G-05 | 5 ug | $259 | |
M336-380G-10 | 10 ug | $380 | |
M336-380G-BULK | BULK | Contact Us |
Overview:
METTL16 (Methyltransferase-like protein 16) is an RNA N6-methyltransferase that methylates adenosine residues at the N6 position of a subset of RNAs. METTL16 methylates the 3’ UTR of the SAM synthetase (MAT2A) mRNA and U6 snRNA (1,2), thereby regulating S-adenosylmethionine homeostasis as well as pre-mRNA splicing. These modifications on viral RNAs are believed to influence the expression of viral genes, the replication of virus and the generation of progeny virions (3).
Gene Aliases:
METT10D; MGC3329
Genbank Number:
References:
1. Shima, H. et al: S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1. Cell Rep. 2017,21:3354–3363.
2. Warda, AS. et al: Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017,18:2004–2014.
3. Dang, W. et al: N6-methyladenosine and viral infection. Front. Microbiol. 2019,10:417.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~98 kDa
There are no related publications available for this product.
Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Metabolic Disorder, Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology
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