Recombinant full-length mouse 14-3-3 theta was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. Y84-30BH
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
Y84-30BH-20 | 20 ug | $314 | |
Y84-30BH-50 | 50 ug | $545 | |
Y84-30BH-BULK | BULK | Contact Us |
Overview:
14-3-3 theta (also known as tyrosine 3-monooxygenase /tryptophan 5-monooxygenase activation protein, theta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Through interaction with ASK1, c-jun NH-terminal kinase, and p38 mitogen-activated protein kinase (MAPK), 14-3-3 theta plays an important role in controlling apotopsis (1). Induced expression of 14-3-3 theta protein has been reported in patients with amyotrophic lateral sclerosis. Additionally, 14-3-3 theta has been observed to mediate nucleo-cytoplasmic shuttling of the N protein (coronavirus nucleocapsid protein) which causes severe acute respiratory syndrome (2).
Gene Aliases:
Ywhaq; 2700028P07Rik; AA409740; AU021156; R74690
Genbank Number:
References:
1. Lau, J.M. et al: The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007, 27(4):1455-66.
2. The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation.J Virol. 2005 Sep;79(17):11476-86.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
32 kDa
There are no related publications available for this product.
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