Recombinant human LZK (1-427) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M21-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M21-11G-05 | 5 ug | $226 | |
M21-11G-10 | 10 ug | $325 | |
M21-11G-BULK | BULK | Contact Us |
Overview:
Leucine zipper-bearing kinase (LZK) is a member of MLK protein family that activates the c-Jun-NH2 terminal kinase pathway by acting as a mitogen‐activated protein kinase kinase kinase (MAPKKK) (1). LZK forms dimers/oligomers through its dual leucine zipper‐like motif that is required for activation of the JNK pathway. LZK has also been shown to activate NF‐κB‐dependent transcription through IKK activation. Antioxidant protein-1, molecule found in the mitochondria, modulates the LZK‐induced NF‐κB activation (2).
Gene Aliases:
MAP3K13, MLK, MEKK13
Genbank Number:
References:
1. Ikeda, A. et. al: Identification and characterization of functional domains in a mixed lineage kinase LZK. FEBS Letters. 488(3):190-195, 2001.
2. Masaki, M. et. al: Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. Eur. J. Biochem. 270, 76–83, 2003.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. 75 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology
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