Recombinant full-length human PKCbeta II was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. P63-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P63-10G-05 | 5 ug | $160 | |
P63-10G-10 | 10 ug | $226 | |
P63-10G-BULK | BULK | Contact Us |
Overview:
PKCβ II is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol and phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways (1). PKCβ II has been reported to be involved in many different cellular functions such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption (2).
Gene Aliases:
PRKCB1; PKCB2; PRKCB1; PRKCB (X07109)
Genbank Number:
References:
1. Greenham, J. et al: Elucidation of the exon-intron structure and size of the human protein kinase C beta gene (PRKCB). Hum. Genet. 103: 483-487, 1998.
2. Su, T T. et al: PKC-beta controls I-kappa-B kinase lipid raft recruitment and activation in response to BCR signaling. Nature Immun. 3: 780-786, 2002.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. Refer to lot specific technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~105 kDa
Yang Weiwei et al., EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-KB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis Molecular Cell November 2012 10.1016/j.molcel.2012.09.028
Dilworth David et al., The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability Nucleir Acid Research 10.1093/nar/gky008
J. Coultrap Steven et al., Improving a Natural CaMKII Inhibitor by Random and Rational Design PLoS One October 2011 10.1371/journal.pone.0025245
Qiu Chen Jin et al., Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system Analytical Biochemistry November 2013 10.1016/j.ab.2013.07.022
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
et al., Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9 Molecular Pharmacology April 2020
Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases
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