Recombinant human full-length CDK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C30-14G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C30-14G-20 | 20 ug | $215 | |
C30-14G-50 | 50 ug | $435 | |
C30-14G-BULK | BULK | Contact Us |
Overview:
CDK3, associates with cyclin E, is a member of the cyclin-dependent protein kinase family and promotes entry into S phase, in part by activating members of the E2F family of transcription factors. CDK3 can associate with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. The CDK3 gene has been mapped to chromosomal location of 17q22-qter, telomeric to the BRCA1 gene by somatic cell hybrids analysis (1). The presence of a single point mutation in the CDK3 gene from several Mus musculus strains commonly used in the laboratory has been reported (2).
Gene Aliases:
Cyclin-dependent kinase 3, cell division protein kinase 3, CDKN3
Genbank Number:
References:
1. Bullrich, F. et al: Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27-Kip1, to regions involved in human cancer. Cancer Res. 55: 1199-1205, 1995.
2. Ye, X. et al: A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. Proc. Nat. Acad. Sci. 98: 1682-1686, 2001.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~61 kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
Cancer, Cell Cycle, Ser/Thr Kinases
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