Recombinant full-length human PDE6C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P94-34CG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P94-34CG-20 | 20 ug | $215 | |
P94-34CG-50 | 50 ug | $435 | |
P94-34CG-BULK | BULK | Contact Us |
Overview:
PDE6C or phosphodiesterase 6C, cGMP-specific, cone, alpha prime encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. PDE6C protein consists of 22 exons spanning approximately 48 kb of genomic DNA. The intron-exon structure of human PDE6C is very similar to that of rod PDE6B (1). A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene and mutations in PDE6C are associated with cone dystrophy type 4 (COD4) (2).
Gene Aliases:
PDEA2
Genbank Number:
References:
1. Chang, B. et.al: A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene. Proc. Nat. Acad. Sci. 106: 19581-19586, 2009.
2. Piriev, N. I. et.al: Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha-prime subunit (PDEA2) and its chromosomal localization to 10q24. Genomics 28: 429-435, 1995.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~125 kDa
There are no related publications available for this product.
Cardiovascular Disease, Inflammation, Phosphodiesterases
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