Overview:

CRBN (Cereblon) and DDB1 (DNA damage-binding protein 1) are proteins that play crucial roles in various cellular processes, including DNA repair, cell cycle regulation, and protein degradation. CRBN is a substrate receptor protein, while DDB1 acts as an adaptor protein within the Cullin-RING ubiquitin ligase (CRL) E3 ligase complex. This complex plays a critical role in the ubiquitin proteasome pathway, which controls the targeted degradation of specific proteins. Understanding the intricate roles of CRBN and DDB1 in cellular processes is crucial for deciphering their potential as therapeutic targets and advancing our knowledge of various diseases, particularly cancer, where dysregulation of these proteins has been observed.

Genbank Number:

NM_016302
NM_001923

References:

1. Chamberlain PP, Lopez-Girona A, Miller K, et al. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat Struct Mol Biol. 2014;21(9):803-809. doi:10.1038/nsmb.2874
2. Ito T, et al. (2010). Identification of a primary target of thalidomide teratogenicity. Science, 327(5971), 1345-1350.
3. Sugasawa K, et al. (2005). A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes & Development, 19(17), 2192-2203.