Protein kinases are a family of pivotal enzymes with 518 members implicated in various processes of signal transduction, constituting over 2% of the human genome. Kinases regulate cell signaling pathways by phosphorylating their physiological substrates. They catalyze the transfer of γ-phosphate from ATP or GTP to the hydroxyl groups of serine, threonine and tyrosine residues on the substrate proteins or the glycosyl moieties in lipids. Kinase deregulation could lead to the changes in kinase enzymatic activity, subcellular localization, stability of kinase, protein-protein interactions, and thereby aberrant activation of downstream signaling pathways that underlie all major human pathological conditions such as cancer, cardiovascular disease, metabolic disorders, and more.
SignalChem offers a broad range of recombinant kinases of superior purity and activity to assist the global academic research and drug discovery efforts with the focus on kinases. Its active kinase product line is one of the most comprehensive in the world in terms of the coverage and has been utilized by many pharmaceutical companies in their drug discovery programs. An in-house product development team with over 100 years of combined experience in kinase biochemistry is behind the production and quality control of all the kinase-related products as well as the method development for activity assays.