HtrA (also designated as DegP) is a trypsin-like serine protease which contains PDZ domain and involves in heat-shock response, chaperone function, and apoptosis (1). Analysis of strains with the htrA (S234A) catalytic site mutation showed that the proteolytic activity of HtrA selectively repressed competence when translational fidelity was high but not when accuracy was low (3).
1. Ge X. et.al: DegP primarily functions as a protease for the biogenesis of beta-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli. FEBS J. 2013 Dec 26. doi: 10.1111/febs.12701.
2. Stevens KE. et.al: Competence in Streptococcus pneumoniae is regulated by the rate of ribosomal decoding errors. MBio. 2011 Sep 20;2(5). pii: e00071-11.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cell Cycle, Neurobiology, Ser/Thr Kinases