Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
U231-63R-100	100 ug	$595
U231-63R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

U231-63R-100

100 ug

$595

U231-63R-BULK

BULK

Overview:

UBE2N (UBC13) or ubiquitin-conjugating enzyme E2N is a member of the E2 ubiquitin-conjugating enzyme family which plays a role in DNA post-replication repair. UBE2N gene encodes a novel human E2 that may be involved in protein degradation in the muscles and testis (1). UBE2N plays a role in initiation of homologous recombination during double-strand break repair (2). UBE2N activity may have therapeutic uses in controlling inflammatory responses and it is also important in the induction of immune responses.

References:

1. Yamaguchi, T. et.al: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. J. Biochem. 120: 494-497, 1996.

2. Zhao, G. Y. et.al: A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Molec. Cell 25: 663-675, 2007.

Specificity:

Recognizes the UBE2N (UBC13) protein

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

UBE2N (UBC13) antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UBE2N (UBC13).

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of UBE2N in human small intestine cell lysates with UBE2N antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.