Recombinant human TYRO3 (455-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T22-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T22-11G-05 | 5 ug | $226 | |
T22-11G-10 | 10 ug | $325 | |
T22-11G-BULK | BULK | Contact Us |
Overview:
TYRO3 receptor protein tyrosine kinase together with AXL and MER form the AXL/TYRO3 family of receptor tyrosine kinases (1). Members of this family play an essential role in spermatogenesis, immunoregulation, and phagocytosis. In addition to signal transduction, members of this family of receptor tryrosine kinases participate in cell adhesion (2). Gas6, a product of growth arrest-specific gene, activates the kinase activity of all three receptors. TYRO3 is expressed in the brain (where it is involved in the protection of neurons from apoptosis), expressed in lymphoid, vascular and reproductive tissue and in primary and tumor cell lines.
Gene Aliases:
BYK; RSE; Dtk; Sky; Tif; Brt
Genbank Number:
References:
1. Angelillo-Scherrer, A. et al: Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J. Clin. Invest. 2005; 115: 237-246.
2. Liao, X. et al: Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk. Mammalian Genome, 1996. 7: 395-396.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~77 kDa
Zhang Zaihui et al., Discovery of novel TAM family kinase inhibitors Cancer Research April 2014 10.1158/1538-7445.AM2014-2716
Zhang Zaihui et al., Novel and selective Axl inhibitors Cancer Research April 2014 10.1158/1538-7445.AM2014-1746
Abu-Thuraiaa Afnan et al., Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion Molecular and Cellular Biology October 2014 10.1128/MCB.00764-14
et al., Regulation of ferredoxin-catalyzed photosynthetic phosphorylations. Proceedings of the National Academy of Sciences of the United States of America December 1975
Cancer, Inflammation, Invasion/Metastasis, Neurobiology, Receptor Tyrosine Kinases
STAY CONNECTED
Fax: 1-604-232-4601