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CyclinC Protein

Recombinant full-length human CyclinC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C80-30G


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Catalog No. Pack Size Price (USD)
C80-30G-20 20 ug $215
C80-30G-50 50 ug $435
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Overview:

Cyclin C is a member of the cyclin family of proteins and interacts with the cyclin-dependent kinase 8 (CDK8) and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human Hematopoietic stem cells (1). Cyclin C can also combine with CDK3 to stimulate Rb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently (2).


Gene Aliases:

CCNC, CycC


Genbank Number:


References:


1. Miyata, Y. et al: Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells. 2010 Feb; 28(2): 308-17.

2. Ren, S. et al: Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell. 2004 Apr 16;117(2):239-51.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~55 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


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  CyclinE1 Protein, C82-30G


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