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Beta-synuclein Protein

Recombinant full length human Beta-synuclein was expressed in E. coli cells using an N-terminal His tag.
Catalog No. S22-30BH




Catalog No. Pack Size Price (USD)
S22-30BH-20 20 ug $105
S22-30BH-50 50 ug $160
S22-30BH-BULK BULK Contact Us  


Overview:

Beta-synuclein is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Beta-synuclein is highly homologous to alpha-synuclein which is abundantly expressed in the brain and putatively inhibits phospholipase D2 selectively. Beta-synuclein may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. Beta-synuclein is shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease but no direct relation to Parkinson disease has been established (1). An alteration in Beta-synuclein may impair its normal inhibitory action on the formation of toxic alpha-synuclein fibrils, thereby indirectly contributing to disease pathogenesis (2).


Gene Aliases:

(None)


Genbank Number:


References:


1. Ohtake, H. et.al: Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology 63: 805-811, 2004.

2. Lavedan, C. et.al: Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Res. 5: 401-402, 1998.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~19 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Neurobiology


RELATED PRODUCTS


  Alpha-synuclein Protein, S22-30H

  Gamma-synuclein Protein, S22-30CH


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