Recombinant full length human Beta-synuclein was expressed in E. coli cells using an N-terminal His tag.
Catalog No. S22-30BH
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S22-30BH-20 | 20 ug | $105 | |
S22-30BH-50 | 50 ug | $160 | |
S22-30BH-BULK | BULK | Contact Us |
Overview:
Beta-synuclein is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Beta-synuclein is highly homologous to alpha-synuclein which is abundantly expressed in the brain and putatively inhibits phospholipase D2 selectively. Beta-synuclein may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. Beta-synuclein is shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease but no direct relation to Parkinson disease has been established (1). An alteration in Beta-synuclein may impair its normal inhibitory action on the formation of toxic alpha-synuclein fibrils, thereby indirectly contributing to disease pathogenesis (2).
Gene Aliases:
(None)
Genbank Number:
References:
1. Ohtake, H. et.al: Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology 63: 805-811, 2004.
2. Lavedan, C. et.al: Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Res. 5: 401-402, 1998.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~19 kDa
There are no related publications available for this product.
Cancer, Neurobiology
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