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Recombinant full length human DUSP22 was expressed in E.coli cells using a N-terminal GST tag.
Catalog No. D22-20G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D22-20G-05 | 5 ug | $226 | |
D22-20G-10 | 10 ug | $325 | |
D22-20G-BULK | BULK | Contact Us |
Overview:
Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues) (1). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling (2).
Gene Aliases:
VHX, JKAP, JSP1, MKPX
Genbank Number:
References:
1. Andres, A. et al: VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. J Biol Chem. 2004 Jul 30; 279(31): 32586-91. Epub 2004 May 11.
2. Shen, Y. et al: Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24): 13613-8.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~43 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway, Neurobiology, NfkB Pathway, Phosphatases
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