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Recombinant full-length Drosophila melanogaster tag-free Tau-361 was expressed in E. coli cells.
Catalog No. T09B-54N
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T09B-54N-20 | 20 ug | $160 | |
T09B-54N-50 | 50 ug | $336 | |
T09B-54N-BULK | BULK | Contact Us |
Overview:
Drosophila melanogaster Tau-361 and human Tau-441 are homologs with amino acid sequence similarities and share functional properties in microtubule binding and stability (1). Tau-361 exhibits 46% identity and 66% similarity with human Tau-441. Tau-361 contains five putative microtubule binding domain (MTBD) repeats, but does not contain the N-terminal MTBD repeats found in human Tau-441 (2). Drosophila melanogaster is a widely used powerful model organism utilized to investigate in vivo toxicity of proteins linked to neurodegenerative diseases, particularly Alzheimer’s disease where the accumulation of post-translationally modified Tau species leads to the formation of intracellular neurofibrillary tangles and subsequent neuronal death (1,2).
Genbank Number:
References:
1. Burnouf, S. et al: Deletion of endogenous Tau proteins is not detrimental in Drosophila. Sci Rep. 2016; 6: 23102.
2. Heidary, G. and Fortini, M.E.: Identification and characterization of the Drosophila tau homolog. Mech. Dev. 2001; 108: 171-178.
Alternative Name(s):
BcDNA:RE16764; CG12881; CG31057; CG31058; CG34294; CG45110; CG5606; d-tau; Dmel\CG45110; dTau; dTAU; Tau
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Molecular Weight:
Observed MW ~53 kDa. Calculated MW ~41 kDa.
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